Pfizer Pro Logo

Side Effects

As with other drugs, you may experience some side effects with ARTHROTEC (diclofenac sodium/misoprostol). Usually these are mild, occur within the first few weeks of taking the drug, and go away after a week. The most common side effects are:

  • Stomach pain
  • Diarrhea
  • Upset stomach
  • Nausea
  • Gas

Talk to your doctor if these problems last longer than a week. A change in your daily dose may solve the problem.

Next: About Arthritis


ARTHROTEC is a medicine that relieves the pain of arthritis while protecting your stomach.

Important Safety Information
ARTHROTEC should not be taken by women who are pregnant or who may become pregnant. ARTHROTEC can cause miscarriage, often associated with bleeding, which may result in other serious complications.

Like all prescription NSAIDs, ARTHROTEC may increase the chance of heart attack or stroke that can lead to death. It should not be used right before or after certain heart surgeries.

Also, like all prescription NSAIDs, ARTHROTEC can cause serious stomach and intestine problems, such as bleeding and ulcers, which can occur without warning and may cause death. Elderly patients are at increased risk for stomach bleeding and ulcers.

Prescription NSAIDs can cause serious skin reactions which may cause death.

Tell your doctor if you:

  • Are pregnant or may become pregnant
  • Have a history of ulcers or bleeding in the stomach or intestines
  • Have high blood pressure or heart failure
  • Have kidney or liver problems

Prescription ARTHROTEC should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

For more information about ARTHROTEC and other NSAIDs, please see the Medication Guide. For further information on ARTHROTEC, please see full Prescribing Information.

Pfizer Helpful Answers Pfizer Helpful Answers


The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.


AHP00059