ARTHROTEC (diclofenac sodium/misoprostol tablets) should not be taken by women who are pregnant. ARTHROTEC may cause miscarriage, premature birth, birth defects, or other serious complications during pregnancy. If you become pregnant during therapy with ARTHROTEC, stop taking ARTHROTEC and contact your doctor immediately. Do not give ARTHROTEC to anyone else. It may be dangerous for another person, especially a woman who may be or could become pregnant.
Like other nonsteroidal anti-inflammatory drugs (NSAIDs), ARTHROTEC may increase the chance of a heart attack or stroke that can lead to death. This chance increases with longer use and in people who have heart disease.
ARTHROTEC should not be used right before or after a heart surgery called a "coronary artery bypass graft (CABG)."
Also, like other NSAIDs, ARTHROTEC can cause ulcers and bleeding in the stomach and intestines at any time during treatment, which can occur without warning and may cause death. Elderly patients are at greater risk for serious gastrointestinal events.
Do not take ARTHROTEC if you are allergic to diclofenac or misoprostol; if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine; and if you have active gastrointestinal bleeding, severe kidney or liver problems, or severe heart failure.
ARTHROTEC is contraindicated in patients with active gastrointestinal bleeding.
The use of ARTHROTEC with concomitant NSAIDs including COX-2 inhibitors should be avoided.
Tell your doctor if you have a history of high blood pressure, heart failure, fluid retention, ulcer disease, gastrointestinal bleeding, kidney disease or liver disease.
Prescription NSAIDs, including ARTHROTEC, can cause serious skin reactions which may cause death. Stop taking ARTHROTEC immediately at the first appearance of skin rash or any other signs of hypersensitivity and contact your doctor as soon as possible.
The most common side effects for ARTHROTEC are abdominal pain, diarrhea, indigestion, nausea, and gas.
ARTHROTEC should only be used exactly as prescribed at the lowest dose possible and for the shortest time needed.